Last Modified: November 06, 2025
APHIS invests $100 million in funding for innovative projects aimed at combating highly pathogenic avian influenza (HPAI).
The selected projects advance prevention, therapeutics, vaccine development, and research to understand transmission and improve biosecurity. APHIS selected these projects through a competitive process, in consultation with the U.S. Department of Health and Human Services (HHS). Recipients include vaccine manufacturers, universities, producer organizations, and other research partners.
No HPAI vaccine has been authorized for use at this time, except on a case-by-case basis in certain endangered or zoo species. APHIS will continue to assess promising candidates in coordination with HHS.
Funded Projects
Browse the list of funded projects by priority topic below or download the PDF version (163.9 KB).
| ID | Recipient | Title |
|---|---|---|
| APP-92382 | Kansas State University | Insects for antigen production and delivery: a novel oral vaccination platform for HPAI |
| APP-92465 | University of Minnesota | Development of broadly protective vaccines against HPAI viruses |
| APP-92468 | Duke University School of Medicine | Vaccine-based control strategies to mitigate HPAI outbreaks in layer chickens |
| APP-96335 | Georgia Tech Applied Research Corp | Novel poultry vaccine platform: artificial intelligence design and high throughput antigen testing system for live bacteria vaccine development against HPAI (H5N1) |
| APP-96339 | State University of New York | Novel feedable yeast vaccines for broad bird protection against HPAI in poultry |
| APP-96356 | University of Washington | Targeting avian influenza with innovative phage-based vaccines |
| APP-96399 | University of Minnesota | Development of a novel lactococcal phage and mucosal immunity-based H5N1 HPAI vaccine for poultry |
| APP-96403 | University of Maryland, College Park | Development of non-replicating adenovirus vectored vaccines with pan-H5 cross-clade reactivity to protect chickens from HPAI |
| APP-96419 | Kansas State University | Development of HPAI virus (H5N1) subunit vaccines and a DIVA diagnostic lateral flow device |
| APP-96478 | Centivax, Inc. | Centi-Poult-H5: a broadly protective vaccine for HPAI in poultry |
| APP-96515 | Colorado State University | Exploiting probiotic delivery of a novel oral subunit vaccine against HPAI in poultry |
| APP-96556 | University of Missouri | Novel vaccine and strategy to control HPAI H5 viruses |
| APP-96565 | Texas A&M Agrilife Research | Marek’s disease virus vector vaccines for H5 HPAI control in chickens |
| APP-96593 | Iowa State University of Science and Technology | Protection and immunity induced by avian influenza nanovaccine (AI-nanovax) in chickens |
| APP-96616 | University of Georgia Research Foundation, Inc. | Mass vaccination-ready, reassortment-impaired live virus vaccines against HPAI |
| APP-97478 | Cyanvac LLC | PIV5-based influenza H5N1 vaccine for poultry immunization |
| APP-97565 | Louisiana State University | Nanobody-directed, M-cell-targeted mucosal vaccine against HPAI H5N1 clade 2.3.4.4b in poultry |
| ID | Recipient | Title |
|---|---|---|
| APP-92487 | University of Georgia Research Foundation, Inc. | Novel immunoprophylaxis strategies to combat avian influenza |
| APP-92570 | University of Minnesota | Beyond vaccines: harnessing trained immunity to strengthen poultry resilience against HPAI |
| APP-96411 | Utah State University | Decoding the poultry-HPAI interactome: an integrative pipeline for targeted therapeutics against HPAI |
| APP-96431 | Resonant Health Inc. | Preventing HPAI transmission on poultry farms using radiofrequency antivirals |
| APP-96442 | University of Georgia Research Foundation, Inc. | Anti-HPAI effects of tannins in poultry |
| APP-96460 | Ohio State University | Precision gene editing to confer avian influenza resistance in chickens by targeting viral entry pathways |
| APP-96583 | Purdue University | Fogging the threat: a novel therapeutic approach to suppress HPAI transmission in poultry facilities |
| APP-96617 | University of Georgia Research Foundation, Inc. | Harnessing the power of nutrition against avian influenza |
| APP-97282 | University of North Carolina at Chapel Hill | Development of poultry specific HPAI antivirals for feed-based delivery |
| APP-97439 | University of Pennsylvania | Evaluation of efficacy of bean powder in neutralization, prevention of infection and transmission of contemporary H5N1 HPAIV strains in chickens and turkeys |
| APP-97464 | A-New Bio Inc. | Engineering multigenic resistance to avian influenza in chickens |
| APP-97487 | University of Michigan | AI-driven discovery of resistance-resilient poultry antivirals targeting influenza cap endonuclease |
| APP-97500 | Seek Labs, Inc. | Novel CRISPR based mediated therapeutics for HPAI in poultry |
| APP-97595 | Purdue University | Aerosolized soluble Niclosamide for control of HPAI |
| ID | Recipient | Title |
|---|---|---|
| APP-88108-EMAIL | United States Geological Survey | Building a HPAI environmental surveillance toolbox for early detection and rapid outbreak response |
| APP-92460 | University of Nebraska | Comprehensive HPAI surveillance in diverse landscapes; development of holistic sample and testing methodologies for early detection |
| APP-92546 | Washington University | AirAVIAN: Airborne Avian Influenza Identification And Notification system |
| APP-93388 | Indiana University | Enhancing poultry farm biosecurity using ultraviolet-C light technology to prevent avian influenza virus contamination |
| APP-96350 | Ande Corp | Rapid HMAC H5N1 diagnostic with ability to detect influenza A subtypes and strains, increased sensitivity, and resistance to assay destruction by mutation and reassortment to enable dramatically enhanced H5N1 detection in unvaccinated and vaccinated poultry |
| APP-96365 | University of Minnesota | Turkeys are not big chickens: turkey-specific and physiologically relevant models to study avian influenza A infections and therapeutics |
| APP-96413 | University of Michigan | Understanding the role of rapid pH dynamics in the natural and engineered inactivation of influenza aerosols in poultry production facilities |
| APP-96418 | University of Minnesota | Reducing the risk of barn to barn spread of H5Nx influenza on infected poultry premises |
| APP-96467 | St. Jude Children's Research Hospital Inc | Investigating novel mechanisms of local area spread of HPAIV in poultry |
| APP-96492 | North Carolina State University | Uncovering the main modes of transmission of HPAI at the farm and barn levels under optimized ventilation |
| APP-96532 | University of Pittsburgh | Innovative, field-deployable, and highly specific diagnostic platforms for HPAI detection in poultry, wild birds, and environmental reservoirs |
| APP-96560 | University of Missouri | A dictionary of cellular communication networks in the chicken lung and their importance for achieving HPAI resistance |
| APP-96572 | Colorado State University | Avian influenza in poultry on the Navajo Nation |
| APP-96576 | American Type Culture Collection | Reference materials for HPAI in poultry that support the development of biosecurity strategies, novel therapeutics, and vaccines |
| APP-96581 | Colorado State University | Identifying routes of transmission and assessing mitigation efforts against HPAI H5N1 clade 2.3.4.4b in poultry |
| APP-96621 | University of California at Riverside | Unveiling HPAI transmission dynamics: developing a novel AI-driven proteomic sentinel |
| APP-97299 | University of Michigan | Establishing the role of peridomestic mammals in maintaining H5N1 among poultry and promoting biosecurity at the wildlife-poultry interface |
| APP-97328 | Texas A&M Veterinary Medical Diagnostic Laboratory | Strategies to reduce costs and expand testing options for influenza real-time RT-PCR |
| APP-97349 | Translational Genomics Research Institute | Leveraging wildlife networks to strengthen surveillance and early detection of HPAI in support of poultry sector preparedness |
| APP-97410 | Montana State University | Bench to barn: leveraging poultry intestinal organoids to rapidly evaluate interventions that reduce HPAI transmission in domestic chickens |
| APP-97419 | Kansas State University | Protecting U.S. agriculture from HPAI: field-ready acoustic solutions to keep infected wild birds away commercial poultry meat and egg farms |
| APP-97420 | Indiana University | Integrated aquatic and terrestrial surveillance for HPAI in Indiana |
| APP-97440 | Canon Virginia Inc. | Sapphire molecular diagnostic platform for rapid HPAI detection |
| APP-97451 | Electradx Molecular LLC | SOAR, Surveillance and Onsite Avian Influenza Response |
| APP-97470 | Columbia University in the City of New York | Evaluating far-UVC lighting for improved biosecurity on poultry farms |
| APP-97529 | Minnesota Turkey Research and Promotion Council | Transitioning to sustainable HPAI control strategies in poultry populations
|
| APP-97632 | Radiolife | Novel Reagent-less Radio Frequency and AI-based Diagnostic Device for Rapid Detection of Highly Pathogenic Avian Influenza (HPAI) in Poultry |
Contact Us
For questions about HPAI Poultry Innovation Grand Challenge funding, email sm.ap.hpai.challenge@usda.gov.