Detections of Highly Pathogenic Avian Influenza in Mammals

Last Modified: April 01, 2024
Seals on rocks

There are many species that are potentially susceptible to highly pathogenic avian influenza (HPAI). In addition to birds and poultry, H5N1 viruses have been detected in some mammals (see list below). Infection may cause illness, including severe disease and death in some cases.

Table Notes

Date Detected: Indicates the date when a positive detection was obtained by the development a l RRT PCR targeting the Eurasian lineage goose/Guangdong H5 clade 2.3.4.4b.

HPAI Strain:

EA = Eurasian; AM = North American; the EA H5 (2.3.4.4) viruses are highly pathogenic to poultry.

EA/AM: reassortant of H5 goose/Guangdong and North American wild bird lineage

Virus lineage, subtype, and pathotype per cleavage site analysis are determined from sequence data direct from the sample or virus isolate. An incomplete subtype indicates either (1) the specimen is pending virus isolation and/or sequencing results, or (2) the specimen was detected by the developmental H5 RRT PCR targeting the Eurasian lineage goose/Guangdong H5 clade 2.3.4.4b but could not be further characterized, often due to a low level of virus or viral RNA present in a given sample.

About Avian Influenza

Avian influenza is caused by influenza Type A virus (influenza A). Avian-origin influenza viruses are broadly categorized based on a combination of two groups of proteins on the surface of the influenza A virus: hemagglutinin or “H” proteins, of which there are 16 (H1–H16), and neuraminidase or “N” proteins, of which there are 9 (N1–N9). Many different combinations of “H” and “N” proteins are possible. Each combination is considered a different subtype, and related viruses within a subtype may be referred to as a lineage. Avian influenza viruses are classified as either “low pathogenic” or “highly pathogenic” based on their genetic features and the severity of the disease they cause in poultry. Most viruses are of low pathogenicity, meaning they cause no signs or only minor clinical signs of infection in poultry.