Vesicular Stomatitis Virus

Last Modified: April 06, 2024
Close-up of a brown horse in a green pasture.

Vesicular stomatitis is a contagious disease of livestock, mainly affecting horses and cattle. Occasionally, this disease can infect swine, sheep, goats, llamas, alpacas, and even people. It is primarily transmitted by biting flies and midges. The disease causes blister-like sores, among other side effects.

Although vesicular stomatitis rarely causes high mortality rates, it can impact animal movement and international trade, resulting in economic losses for livestock producers. Outbreaks usually occur during warmer months, often along waterways. The Southwestern and Western United States have experienced several outbreaks since 1995, with the most widespread in 2019.

Clinical signs may appear 2 to 8 days after exposure. Here's what to look for:

  • Drooling or frothing at the mouth
    • The first sign of illness is often excessive salivation. If you look inside the mouth, you'll see blanched and raised blisters on the inner surfaces of the lips, gums, tongue, or dental pad.
  • Lesions
    • Blister-like lesions can form around the mouth, nose, sheath, udders, ears, and coronary band (where an animal's hairline meets their hooves). If lesions develop around the coronary band, lameness may occur.
  • Fever
    • You may notice a rise in body temperature before or at the same time lesions first appear.
  • Reluctance to eat
    • The blisters swell and break open, which causes mouth pain, discomfort, and reluctance to eat or drink. This can cause weight loss.

Report Signs of Animal Disease

Producers or owners who suspect an animal disease should contact their veterinarian to evaluate the animal or herd. Find an accredited veterinarian.

Animal health professionals (veterinarians; diagnostic laboratories; public health, zoo, or wildlife personnel; and others) report diagnosed or suspected cases of nationally listed reportable animal diseases to APHIS Area Veterinarians in Charge and to the State animal health official as applicable under State reporting regulations. 

Controlling Vesicular Stomatitis