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Animal and Plant Health Inspection Service
U.S. Department of Agriculture
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Notifications Process (Retired)
This process was discontinued April 5, 2021  

As part of the revised regulations, the former notification process was discontinued on April 5, 2021. All applications must now be submitted through the permitting process. APHIS will process notifications it received on or before April 4, 2021, and acknowledged notifications will remain effective until expiration. Applicants can check the status of a notification at the link below.

Check the Status of a Notification

View Guidance and Resources for Notifications

Learn more about the SECURE Rule 

Apply for Permits Online
On April 5, 2021, APHIS transitioned from ePermits to APHIS eFile. All applicants must use APHIS eFile to apply for permits for organisms developed using genetic engineering. APHIS will process any applications submitted in the retired ePermits system through April 4, 2021. Compliance reports related to these applications must submitted in ePermits. APHIS will reject any applications submitted in ePermits on or after April 5, 2021.

Apply Online

Learn More about APHIS eFile

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