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Animal and Plant Health Inspection Service
U.S. Department of Agriculture
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On April 5, 2021, APHIS transitioned from ePermits to APHIS eFile. All applications for organisms developed using genetic engineering are now being submitted through APHIS eFile. Any applications submitted in the retired ePermits system through April 4, 2021, will complete processing in ePermits. Compliance reports related to these applications must also be submitted in ePermits.  On March 28, 2022, APHIS will launch updates to APHIS eFile that will make it easier to submit a permit application. APHIS' Biotechnology Regulatory Services is offering training on March 29-April 7, 2022, to assist applicants with the updates.

Things to Know Now

  • Consistent with the revised regulations found at 7 CRF part 340, notifications are no longer available.
  • ePermits remains available for access to past BRS permits and notifications, and for submission of certain PPQ and VS permits. Application data from ePermits will not be available in APHIS eFile.
  • Any applications submitted in ePermits through April 4, 2021, will complete their life cycle in ePermits. Compliance reports related to these applications must be submitted in ePermits.
  • Courtesy permits are not available under the revised regulations found at 7 CRF part 340, or in APHIS eFile.

About APHIS eFile

The APHIS eFile system allows applicants to electronically apply for APHIS form 2000—permits for the importation, interstate movement, and environmental release of organisms developed through genetic engineering that are plant pests or may pose plant pest risks. APHIS eFile also allows applicants to request labels, submit reports and notices, and report potential noncompliance.

Applicant Portal
Registered users in APHIS eFile have access to a personalized Applicant Portal that provides easy navigation and allows users to quickly access the information.  

Organization Accounts
Applicants may create or join shared accounts that enable team collaboration and management of applications. Users can share applications and constructs with others in an organization, making records and documents visible to anyone else in the team. 

Previously Submitted Constructs
When preparing new applications, applicants may select and add construct records that were submitted on previous applications in APHIS eFile, saving time on data entry and shortening APHIS response times. 

Applicants may easily communicate with APHIS reviewers using Chatter, a feature with the look and feel of social media platforms. Chatter messages will also appear in the user’s email so applicants can reply through their email client. 

Revising Applications
The application revision feature allows applicants to easily see what sections of their submissions require correction.

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