Chronic Wasting Disease Information |
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Causative Agents - Prions
Bellion, A., W. Seyfert-Brandt, W. Lang, H. Baron, A. Gröner and M. Vey. 2003. Improved conformation-dependent immunoassay: suitability for human prion detection with enhanced sensitivity. J. of General Virology 84:1921-1925.
Chiesa, R., P. Piccardo, E. Quaglio, B. Drisaldi, S. L. Si-Hoe, M. Takao, B. Ghetti and D.A. Harris. 2003. Molecular Distinction between Pathogenic and Infectious Properties of the Prion Protein. J. of Virology 77(13):7611-7622.
Deleault, N.R., R.W. Lucassen and S. Supattapone. 2003. RNA molecules stimulate prion protein conversion. Nature 425: 719-720.
Jobling, M.F., L.R. Stewart, A.R. White, C. McLean, A. Friedhuber, F. Maher, K. Beyreuther, C.L. Masters. C.J. Barrow, S.J. Collins, and R. Cappai. 1999. The Hydrophobic Core Sequence Modulates the Neurotoxic and Secondary Structure Properties of the Prion Peptide 106-126. J. of Neurochemistry 73(4):1557-1565.
Thackray, A.M., M.A. Klein, and R. Bujdoso. 2003. Subclinical Prion Disease Induced by Oral Inoculation. J. of Virology 77(14):7991-7998.
Paramithoiotis, E., M. Pinard, T. Lawton, S. LaBoissiere, V.L. Leathers, W. Zou, L.A. Estey, J. Lamontagne, M.T. Lehto, L.H. Kondejewski, G.P. Francoeur, M. Papadopoulos, A. Haghighat, S.J. Spatz, M. Head, R. Will, J. Ironside, K. O’Rourke, Q. Tonelli, H.C. Ledebur, A. Chakrabartty and N.R. Cashman. 2003. A prion protein epitope selective for the pathologically misfolded conformation. Nature Medicine 9(7):893-899.
Gravenor, M.; Stallard, N.; Curnow, R.; Mclean, A. 2003. Repeated challenge with prion disease: The risk of infection and impact on incubation period. PNAS 100(19)10960-10965.
Bainbridge, J.; Walker, B. 2003. Cell mediated immune responses against human prion protein. Clinical Exp. Immunol 133:310-317.
Bartz, J.; Kincaid, A.; Bessen, R. 2003. Rapid Prion Neuroinvasion following Tongue Infection. Journal of Virology 77(1):83-591.
Liebman, S. 2002. Progress towards an ultimate proof of the prion hypothesis. PNAS 99(14):9098-9100.
Li, R.L.; Liu, T.; Wong, B.S.; Pan, T.; Morillas, M.; Swietnicki, W.; ORourke, K.; Gambetti, P.; Surewicz, W.K.; Sy, M.S. 2000. Identification of an epitope in the C terminus of normal prion protein whose expression is modulated by binding events in the N terminus. Journal of Molecular Biology 301(3):567-573.
O'Rourke, K.I., T.E. Besser, M.W. Miller, T.F. Cline, T.R. Spraker, A.L. Jenny, M.A. Wild, G.L. Zebarth and E.S. Williams. 1999. PrP genotypes of captive and free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease. J. of General Virology 80(10): 2765-2769.
Sigurdson, C.J., T.R. Spraker, M.W. Miller, B. Oesch and E.A. Hoover. 2001. PrPCWD in the mesenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease. J. of General Virology 82: 2327-2334.
Prusiner, S. 1995. The Prion Diseases: Prions, once dismissed as an impossibility, have now gained wide recognition as extraordinary agents that cause a number of infectious, genetic and spontaneous disorders. Scientific American 272(1):48-57.
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